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Article

Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations.

PloS one - 1 Jan 2017

Core Jason Q, Mehrabi Mehrsa, Robinson Zachery R, Ochs Alexander R, McCarthy Linda A, Zaragoza Michael V, Grosberg Anna

Abstract excerpt

Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29149195
DOI: 10.1371/journal.pone.0188256
PMCID: PMC5693421

Genes

LMNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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