MicroRNA-92a negatively regulates neurofibromin 2 and inhibits its tumor suppressive function

Abstract excerpt

<h4>ABSTRACT</h4> Inactivation of the tumor suppressor Merlin leads to the development of benign nervous system tumors of neurofibromatosis type 2. Merlin deficiency is also observed in human malignancies including colorectal and lung cancers. Causes of Merlin inactivation include deleterious mutations in the encoding neurofibromin 2 gene (NF2) and aberrant Merlin proteasomal degradation. Here, we show that NF2 i...

Topics

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• Cancer Mechanisms and Therapy
• Carcinogenesis
• Mutation
• Neurofibromatosis 2
• Neurofibromatosis and Schwannoma Cases
• Neurofibromin 2
• Signal Transduction
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

d4102d65-dbb2-5492-b756-85aa81c2de04

DOI

10.1101/249177