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Article

FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression

6 Feb 2019

Abstract excerpt

Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target, thymidylate synthase (TYMS), which catalyses the de novo pathway for production of deoxythymidine monophosphate. The potent oncogenic forkhead box transcription factor, FOXM1 is is regulated by E2F1 which also controls TYMS. This study reveals a significant role of FOXM1 in 5-FU resistance. Overexpression and knock-down...

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PMID: 30728402
DOI: 10.1038/s41598-018-38017-0

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