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Article

Type I interferons induce autophagy in certain human cancer cell lines

2 May 2013

Abstract excerpt

Autophagy is an evolutionarily conserved cellular recycling mechanism that occurs at a basal level in all cells. It can be further induced by various stimuli including starvation, hypoxia, and treatment with cytokines such as IFNG/IFNγ and TGFB/TGFβ. Type I IFNs are proteins that induce an antiviral state in cells. They also have antiproliferative, proapoptotic and immunomodulatory activities. We investigated...

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PMID: 23419269
DOI: 10.4161/auto.23921

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