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Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>

2022-05-12

Abstract excerpt

Axonemal dynein motors are large multi-subunit complexes that drive ciliary movement. Cytoplasmic assembly of these motor complexes involves several co-chaperones, some of which are related to the R2TP co-chaperone complex. Mutations of these genes in humans cause the motile ciliopathy, Primary Ciliary Dyskinesia (PCD), but their different roles are not completely known. Two such dynein (axonemal) assembly factors...

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Literature Corpus work
d3a6f70e-5e52-52fe-9bc8-cbe01711251c
DOI
10.1101/2022.05.12.491607
Open publication

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Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>DOI 10.1101/2022.05.12.491607
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