Back to search

Article

The <i>Drosophila</i> orthologue of the primary ciliary dyskinesia-associated gene, <i>DNAAF3</i> , is required for axonemal dynein assembly

2021-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans the impairment of these motors through mutation results in the disease, Primary Ciliary Dyskinesia (PCD). Studies in Drosophila have helped to validate several PCD genes whose products are required for cytoplasmic pre-assembly of axonemal dynein motors. Here we report the characterisati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9419d532-a07c-53ff-ad34-7d4cc14000c4
DOI
10.1101/2021.05.11.443597
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>Drosophila</i> orthologue of the primary ciliary dyskinesia-associated gene, <i>DNAAF3</i> , is required for axonemal dynein assemblyDOI 10.1101/2021.05.11.443597
The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly.Semantic proximity
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Semantic proximity
Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>Semantic proximity
Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia.Semantic proximity
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3Semantic proximity
<i>C11orf70</i> mutations causing primary ciliary dyskinesia disrupt a conserved step in the intraflagellar transport-dependent assembly of multiple axonemal dyneinsSemantic proximity
The effect of <i>Dnaaf5</i> gene dosage on primary ciliary dyskinesia phenotypesSemantic proximity
Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.Semantic proximity
CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.Semantic proximity
Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.Semantic proximity
Novel dynein axonemal assembly factor 1 mutations identified using whole‑exome sequencing in patients with primary ciliary dyskinesia.Semantic proximity
DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation.Semantic proximity
Select a neighboring publication to make it the new centre.