HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

doi:10.1371/journal.pgen.1004577

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

PLoS genetics - 1 Sept 2014

Diggle Christine P, Moore Daniel J, Mali Girish, zur Lage Petra, Ait-Lounis Aouatef, Schmidts Miriam, Shoemark Amelia, Garcia Munoz Amaya, Halachev Mihail R, Gautier Philippe, Yeyati Patricia L, Bonthron David T, Carr Ian M, Hayward Bruce, Markham Alexander F, Hope Jilly E, von Kriegsheim Alex, Mitchison Hannah M, Jackson Ian J, Durand Bénédicte, Reith Walter, Sheridan Eamonn, Jarman Andrew P, Mill Pleasantine

Abstract excerpt

Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis. In humans, defects specifically affecting motile cilia lead to chronic airway infections, infertility and laterality defects in the genetically heterogeneous disorder Primary Ciliary Dyskinesia (PCD). Using the comparatively simple Drosophila system, in which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonemal Dyneins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Axoneme

Share to Cilia

Share to Ciliary Motility Disorders

Share to Drosophila

Share to Dyneins

Share to Kartagener Syndrome

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25232951
DOI: 10.1371/journal.pgen.1004577
PMCID: PMC4168999

Genes

DNAAF1
DNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.PMID 25232951Read ↗

Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.Semantic proximity Read ↗

Establishment of the early cilia preassembly protein complex during motile ciliogenesis.Semantic proximity Read ↗

Strongly truncated Dnaaf4 plays a conserved role in Drosophila ciliary dynein assembly as part of an R2TP-like co-chaperone complex with Dnaaf6Semantic proximity Read ↗

Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia.Semantic proximity Read ↗

DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.Semantic proximity Read ↗

Ciliary Dyneins and Dynein Related CiliopathiesSemantic proximity Read ↗

CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.Semantic proximity Read ↗

C11orf70 mutations causing primary ciliary dyskinesia disrupt a conserved step in the intraflagellar transport-dependent assembly of multiple axonemal dyneinsSemantic proximity Read ↗

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.Semantic proximity Read ↗

Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.Semantic proximity Read ↗

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.Semantic proximity Read ↗

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.