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Article

ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.

PLoS genetics - 1 Mar 2018

Cho Kyeong Jee, Noh Shin Hye, Han Soo Min, Choi Won-Il, Kim Hye-Youn, Yu Seyoung, Lee Joon Suk, Rim John Hoon, Lee Min Goo, Hildebrandt Friedhelm, Gee Heon Yung

Abstract excerpt

Zinc finger MYND-type-containing 10 (ZMYND10), a cytoplasmic protein expressed in ciliated cells, causes primary ciliary dyskinesia (PCD) when mutated; however, its function is poorly understood. Therefore, in this study, we examined the roles of ZMYND10 using Zmynd10-/-mice exhibiting typical PCD phenotypes, including hydrocephalus and laterality defects. In these mutants, morphology, the number of motile cilia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29601588
DOI: 10.1371/journal.pgen.1007316
PMCID: PMC5895051

Genes

ZMYND10
DNAI1
DNAI2

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.PMID 29601588Read ↗

Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.Semantic proximity Read ↗

ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.Semantic proximity Read ↗

DYX1C1 is required for axonemal dynein assembly and ciliary motility.Semantic proximity Read ↗

Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia.Semantic proximity Read ↗

Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.Semantic proximity Read ↗

Molecular Insights into Outer Dynein Arm Defects in Primary Ciliary Dyskinesia: Involvement of ZMYND10 and GRP78.Semantic proximity Read ↗

Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>Semantic proximity Read ↗

DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation.Semantic proximity Read ↗

Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).Semantic proximity Read ↗

Physical and functional interaction of Lrrc56 and Odad3 controls deployment of axonemal dyneins in vertebrate multiciliated cellsSemantic proximity Read ↗

Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.Semantic proximity Read ↗

<i>C11orf70</i> mutations causing primary ciliary dyskinesia disrupt a conserved step in the intraflagellar transport-dependent assembly of multiple axonemal dyneinsSemantic proximity Read ↗

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