Article

Tracheostomy in children promotes persistent neutrophilic airway inflammation

2022-08-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tracheostomies in children are associated with significant morbidity, poor quality of life, excess healthcare costs, and excess mortality. The underlying mechanisms facilitating adverse outcomes in tracheostomised children are poorly understood. We aimed to characterise airway host defence in tracheostomised children using serial molecular analyses. <h4>Methods</h4> Tracheal a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3a0ca3d-f019-5bd0-b1bb-8107a769924d
DOI: 10.1101/2022.08.17.22278448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tracheostomy in children promotes persistent neutrophilic airway inflammationDOI 10.1101/2022.08.17.22278448Read

Pathophysiology and genomics of bronchiectasis.Semantic proximity Read

Care Trajectory, Microbiological Ecology, and System-Level Determinants of Tracheitis in Tracheostomized ChildrenSemantic proximity Read

Identification of Three Endotypes in Pediatric Acute Respiratory Distress Syndrome by Nasal Transcriptomic ProfilingSemantic proximity Read

Metatranscriptomic Signatures of Lung Function in Pediatric Hematopoietic Cell Transplant CandidatesSemantic proximity Read

Dynamic Upper and Lower Airway Microbiotas in Paediatric Bronchiectasis Exacerbations: A Pilot StudySemantic proximity Read

Bronchiectasis in children: a systematic review of cytokine profile, immune cell phenotypes and microbiota in bronchoalveolar lavage fluid.Semantic proximity Read

Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patientsSemantic proximity Read

Olfactomedin-4 <sup>+</sup> neutrophils exacerbate intestinal epithelial damage and worsen host survival after <i>Clostridioides difficile</i> infectionSemantic proximity Read

Cohort study investigating the natural history and management of sore throat and tonsillitis among adults in UK general practiceSemantic proximity Read

Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell TransplantationSemantic proximity Read

Idiopathic subglottic stenosis arises at the interface of host and pathogenSemantic proximity Read

Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia.Semantic proximity Read