Article
Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia.
American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2020
Willis Kent A, Siefker David T, Aziz Michael M, White Catrina T, Mussarat Naiha, Gomes Charles K, Bajwa Amandeep, Pierre Joseph F, Cormier Stephania A, Talati Ajay J
Abstract excerpt
During the newborn period, intestinal commensal bacteria influence pulmonary mucosal immunology via the gut-lung axis. Epidemiological studies have linked perinatal antibiotic exposure in human newborns to an increased risk for bronchopulmonary dysplasia, but whether this effect is mediated by the gut-lung axis is unknown. To explore antibiotic disruption of the newborn gut-lung axis, we studied how perinatal...
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