Article

LRRK2 kinase activity is necessary for development and regeneration in <i>Nematostella vectensis</i>

2023-11-04

Abstract excerpt

<h4>Background</h4> The starlet sea anemone, Nematostella vectensis , is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human LRRK2 gene (nvLRRK2). The leucine rich repeat kinase 2 ( LRRK2 ) gene, when mutated, is the most common cause of inherited Parkinson’s Disease (PD). Its protein product (LRRK2) has implications in a variety of cellul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3636992-1860-58bd-a794-4c862ae3c8cd
DOI: 10.1101/2023.11.02.565364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRRK2 kinase activity is necessary for development and regeneration in <i>Nematostella vectensis</i>DOI 10.1101/2023.11.02.565364Read

LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensisSemantic proximity Read

Polo-like kinase 1 regulates growth in juvenile <i>Fasciola hepatica</i>Semantic proximity Read

Loss of <i>lrrk2</i> impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brainSemantic proximity Read

DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspectiveSemantic proximity Read

Transcriptomic analysis reveals a role for the nervous system in regulating growth and development of <i>Fasciola hepatica</i> juvenilesSemantic proximity Read

LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles.Semantic proximity Read

<em>Sarcocystis neurona</em> Protein Kinases: Computational Identification, Evolutionary Analysis and Putative Inhibitor DockingSemantic proximity Read

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional rolesSemantic proximity Read

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common MarmosetsSemantic proximity Read

The Parkinson Disease Gene LRRK2: Evolutionary and Structural InsightsSemantic proximity Read

Wnt/β-catenin signalling underpins juvenile <i>Fasciola hepatica</i> growth and developmentSemantic proximity Read

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.Semantic proximity Read