Article

Prenylation controls proliferation in human pluripotent stem cell-derived cardiomyocytes

2024-07-03

Abstract excerpt

Induction of cardiomyocyte proliferation to replace damaged heart tissue is a promising therapeutic approach. A recent drug screen revealed that cardiomyocytes require the mevalonate pathway for proliferation, although the specific mechanisms are unknown. In this study, we use human pluripotent stem cell-derived cardiomyocytes and cardiac organoids to further interrogate the role of the mevalonate pathway in cardi...

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Literature Corpus work: d30018fa-9fac-55f7-8c96-94e17d3bbaa4
DOI: 10.1101/2024.07.01.601625

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