Article

Elesclomol Diminishes Redox Imbalance in Peripheral Tissues of Mblac1 Knockout Mice

2025-10-31

Abstract excerpt

<h4>Objective: </h4> To determine whether loss of Mblac1, a gene implicated in copper metabolism and Alzheimer’s disease, causes systemic mitochondrial redox imbalance and whether treatment with the copper chaperone elesclomol (ES) can restore this balance. <h4>Methods:</h4> We employed 3D cryo-fluorescence imaging to quantify RR in kidneys and livers of Mblac1 KO mice and their wildtype (WT) littermates. Adult mi...

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Literature Corpus work: d2ccc620-8c39-5db7-9d18-2f0c2aa69ecf
DOI: 10.22541/au.176193932.29598629/v1

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