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Article

Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae.

The Journal of biological chemistry - 2 Oct 2015

Ozeir Mohammad, Pelosi Ludovic, Ismail Alexandre, Mellot-Draznieks Caroline, Fontecave Marc, Pierrel Fabien

Abstract excerpt

The yeast Saccharomyces cerevisiae is able to use para-aminobenzoic acid (pABA) in addition to 4-hydroxybenzoic acid as a precursor of coenzyme Q, a redox lipid essential to the function of the mitochondrial respiratory chain. The biosynthesis of coenzyme Q from pABA requires a deamination reaction at position C4 of the benzene ring to substitute the amino group with an hydroxyl group. We show here that the...

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Identifiers

PMID: 26260787
DOI: 10.1074/jbc.M115.675744
PMCID: PMC4591803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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