Article

Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

2022-04-19

Abstract excerpt

<h4>Summary</h4> Transplantation of human pluripotent stem cell-derived dopaminergic (DA) neurons is an emerging therapeutic strategy for Parkinson’s disease (PD). In this study, we demonstrate, for the first time, that that functional recovery after DA neuron transplant is critically dependent on graft-host integration, and not dependent on graft size or DA neuron content. Specifically, in anticipation of an aut...

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Literature Corpus work: d2770a07-d027-5b7c-be48-a66b63b6d8d3
DOI: 10.1101/2022.04.19.488213

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