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Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia

2022-05-20

Abstract excerpt

<title>Abstract</title> <p>Glucocorticoids (GCs) are a mainstay of contemporary, multi-drug chemotherapy in the treatment of childhood acute lymphoblastic leukemia (ALL), and resistance to GCs remains a major clinical concern. Resistance to GCs is predictive of ALL relapse and poor clinical outcome, and therefore represents a major hurdle limiting further improvements in survival rates. While advances have been m...

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Literature Corpus work
c4b15849-a517-5663-815d-aa771892fe19
DOI
10.21203/rs.3.rs-1617202/v1
Open publication

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Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemiaDOI 10.21203/rs.3.rs-1617202/v1
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