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Article

Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia

24 Sept 2004

Abstract excerpt

Treatment resistance, as indicated by the presence of high levels of minimal residual disease (MRD) after induction therapy and induction consolidation, is associated with a poor prognosis in childhood acute lymphoblastic leukemia (ALL). We hypothesized that treatment resistance is an intrinsic feature of ALL cells reflected in the gene expression pattern and that resistance to chemotherapy can be predicted...

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PMID: 15388585
DOI: 10.1182/blood-2004-04-1552

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