Article

Unique single-nucleotide variations, insertions/deletions and copy number variations in myelodysplastic syndrome during treatment resistance and progression revealed by a single-cell DNA sequencing platform

2022-02-21

Abstract excerpt

<title>Abstract</title> <p>Myelodysplastic syndrome (MDS) is a clonal myeloid neoplasm characterized by ineffective hematopoiesis, cytopenia, dysplasia and clonal instability leading to leukemic transformation. Hypomethylating agents are the mainstay of treatment in higher-risk MDS. However, treatment resistance and disease transformation into acute myeloid leukemia (AML) is observed in the majority patients and...

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Literature Corpus work: d2251856-1c82-5177-813d-41f91ead4aa6
DOI: 10.21203/rs.3.rs-1366306/v1

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