Article

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

2021-10-28

Abstract excerpt

Cardiac dysfunction is a common extrapulmonary complication of severe influenza virus infection. Prevailing models propose that influenza-associated heart dysfunction is indirectly triggered by cytokine mediated cardiotoxicity downstream of the inflamed lung, rather than by direct infection of cardiac tissue. To test the etiology of cardiac dysfunction resulting from influenza virus infection, we generated a novel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d217e1a8-afbe-5b24-b0c6-d9e9d3b0fd62
DOI: 10.1101/2021.10.27.466128

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosisDOI 10.1101/2021.10.27.466128Read

IFITM3 protects the heart during influenza virus infectionSemantic proximity Read

Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.Semantic proximity Read

Reduced Immunity Regulator MAVS Contributes to Non-Hypertrophic Cardiac Dysfunction by Disturbing Energy Metabolism and Mitochondrial HomeostasisSemantic proximity Read

MicroRNA-30a-5p silencing polarizes macrophages toward M2 phenotype to alleviate cardiac injury following viral myocarditis by targeting SOCS1.Semantic proximity Read

Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditisSemantic proximity Read

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19Semantic proximity Read

IFIT3 Knockdown Attenuates Pressure-Overload-Induced Cardiac Inflammation and Remodeling Through a JNK/H3K9 Lactylation-Associated MechanismSemantic proximity Read

Role of non-coding RNAs in the pathogenesis of viral myocarditisSemantic proximity Read

Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated CardiomyopathySemantic proximity Read

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart FailureSemantic proximity Read

Acute adenoviral infection elicits an arrhythmogenic substrate prior to myocarditisSemantic proximity Read

RNA-ssisting immunity to heal the heart: a new frontier in therapeuticsSemantic proximity Read