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Article

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

20 May 2019

Abstract excerpt

Small cell lung cancer (SCLC) is the most aggressive neuroendocrine phenotype of the deadliest human lung cancers. However the therapeutic landscape for SCLC has not changed in over 30 years. Effective treatment and prognosis are needed to combat this aggressive cancer. Herein we report that Ser/Arg repetitive matrix 4 (SRRM4), a splicing activator, is abnormally expressed at high levels in SCLC and thus is a...

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PMID: 31110284
DOI: 10.1038/s41598-019-43100-1

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