Article

A Fine-tuned ProtGPT2 (transformer model) for predicting more virulent SARS-CoV-2 variants and understanding its virulence by biophysical methods

2025-05-26

Abstract excerpt

The emergence of Variants of Concern (VOCs) of SARS-COV2 with increased virulence and transmissibility has been linked to multiple mutations in the RBD region, altering their antigenic properties. In this study, we used a specialized ProtGPT2 model trained on the SARS-COV2 spike protein to forecast probable mutations on the spike protein that have not yet emerged. Upon prediction, we systematically studied the sta...

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Literature Corpus work: d1f5aa2e-3a5a-5adb-a674-a7689ab60345
DOI: 10.22541/au.174829157.77672820/v1

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