Article

A Fine-tuned ProtGPT2 (transformer model) for Predicting more Virulent SARS-CoV-2 variants and understanding its virulence by biophysical methods

2025-01-14

Abstract excerpt

The emergence of Variants of Concern (VOCs) of SARS-COV2 with increased virulence and transmissibility has been linked to multiple mutations in the RBD region, altering their antigenic properties. In this study, we used a specialized ProtGPT2 model trained on the SARS-COV2 spike protein to forecast probable mutations on the spike protein that have not yet emerged. Upon prediction, we systematically studied th...

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Literature Corpus work: 4e0fcf97-9caa-5e9d-b8ba-89987b15587f
DOI: 10.1101/2025.01.13.632691

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