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The role of S477N mutation in the molecular behavior of SARS-CoV-2 spike protein: An in-silico perspective.

Journal of cellular biochemistry - 1 Feb 2023

Mondeali Mozhgan, Etemadi Ali, Barkhordari Khabat, Mobini Kesheh Mina, Shavandi Sara, Bahavar Atefeh, Tabatabaie Fatemeh Hosseini, Mahmoudi Gomari Mohammad, Modarressi Mohammad H

Abstract excerpt

The attachment of SARA-CoV-2 happens between ACE2 and the receptor binding domain (RBD) on the spike protein. Mutations in this domain can affect the binding affinity of the spike protein for ACE2. S477N, one of the most common mutations reported in the recent variants, is located in the RBD. Today's computational approaches in biology, especially during the SARS-CoV-2 pandemic, assist researchers in predicting a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36609701
DOI: 10.1002/jcb.30367

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