Article

A role for the spinal cord cholinergic neuron circadian clock in RNA metabolism and mediating ALS disease phenotypes

2025-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Circadian clocks are encoded by a transcription-translation feedback loop that aligns physiological processes with the solar cycle. Previous work linking the circadian clock to the regulation of RNA-binding proteins (RBPs) and alternative splicing provides a foundation for the vital examination of their mechanistic connections in the context of amyotrophic lateral sclerosis (ALS)—a fatal neurode...

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Literature Corpus work: d1f3c0f5-f8c2-539c-a878-d78ac36e3a08
DOI: 10.1101/2025.05.06.652480

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