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Menin-MLL protein-protein interaction inhibitors: a patent review (2014–2021)

24 Feb 2022

Abstract excerpt

INTRODUCTION: Chromosomal translocations involving the mixed-lineage leukemia (MLL, KMT2A, MLL1) genes result in the production of MLL fusion proteins, which cause abnormal transcriptional regulation leading to acute leukemia (AL). Menin (MEN1) protein is essential for MLL to regulate the expression of related target genes. High-affinity interactions between the amino terminus of MLL proteins and Menin proteins...

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PMID: 35202550
DOI: 10.1080/13543776.2022.2045947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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