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Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

1 Apr 2025

Abstract excerpt

Outbreaks of Bordetella pertussis (BP), the causative agent of whooping cough, continue despite broad vaccination coverage and have been increasing since vaccination switched from whole-BP (wP) to acellular BP (aP) vaccines. wP vaccination has been associated with more durable protective immunity and an induced Th1 polarized memory T cell response. Here, we profile, by a multi-omics approach, the immune response...

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PMID: 40169665
DOI: 10.1038/s41467-025-58460-8

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