Article

Systemic and Mucosal Antibody Correlates of Protection Against Bordetella pertussis in a Controlled Human Infection Model

2026-06-23

Abstract excerpt

<h4>Background</h4> Despite high vaccination coverage, pertussis has resurged globally. Whole-cell (wP) and acellular (aP) pertussis vaccines induce distinct immune profiles, yet immune correlates of protection against infection and symptomatic disease remain incompletely defined. We leveraged a controlled human infection model (CHIM) to identify systemic and mucosal humoral signatures associated with resistance...

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Literature Corpus work: 91804dbd-65be-5f95-9bcb-24f7d6a2f095
DOI: 10.64898/2026.06.18.26355881

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