Article

Mucosal and Systemic Antibodies Associated with Clinical Protection in a Pertussis Controlled Human Infection Model

2026-06-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The engagement of mucosal and systemic immunity in preventing Bordetella pertussis colonization and infection in humans, the impact of prior vaccination on host immunity and protective outcomes, and the dynamics of the host response following exposure remain poorly understood. <h4>Methods</h4> Healthy adults were challenged with increasing colony-forming units (CFUs) dose...

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Literature Corpus work: 5cd96700-18b9-5d85-a0be-4ba2e9c4775d
DOI: 10.64898/2026.06.12.26355530

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