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Tumour-derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8-mediated creatine import in NPM1-mutated acute myeloid leukaemia.

Journal of extracellular vesicles - 1 Nov 2021

Peng Meixi, Ren Jun, Jing Yipei, Jiang Xueke, Xiao Qiaoling, Huang Junpeng, Tao Yonghong, Lei Li, Wang Xin, Yang Zailin, Yang Zesong, Zhan Qian, Lin Can, Jin Guoxiang, Zhang Xian, Zhang Ling

Abstract excerpt

Acute myeloid leukaemia (AML) carrying nucleophosmin (NPM1) mutations has been defined as a distinct entity of acute leukaemia. Despite remarkable improvements in diagnosis and treatment, the long-term outcomes for this entity remain unsatisfactory. Emerging evidence suggests that leukaemia, similar to other malignant diseases, employs various mechanisms to evade killing by immune cells. However, the mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34807526
DOI: 10.1002/jev2.12168
PMCID: PMC8607980

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