Article

Astrocyte-to-Neuron Reprogramming via Neurogenin2: A Dual Strategy for Circuit Restoration and Antioxidant Defense in Congenital Blindness and Deafness

2025-09-09

Abstract excerpt

<h4>Background: </h4> Congenital blindness and deafness are major causes of lifelong disability, characterized by irreversible sensory circuit loss. Current therapies remain limited, particularly because neurons are highly vulnerable to oxidative stress, which exacerbates neurodegeneration and impairs circuit repair. Astrocytes, traditionally regarded as supportive cells, have emerged as crucial regulators of anti...

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Literature Corpus work: d1a2909c-ed55-517c-9c06-3bae2a62924d
DOI: 10.20944/preprints202509.0817.v1

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Astrocyte-to-Neuron Reprogramming via Neurogenin2: A Dual Strategy for Circuit Restoration and Antioxidant Defense in Congenital Blindness and DeafnessDOI 10.20944/preprints202509.0817.v1Read

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