Article
The role of KCNQ1 in mouse and human gastrointestinal cancers.
Oncogene - 17 Jul 2014
Than B L N, Goos J A C M, Sarver A L, O'Sullivan M G, Rod A, Starr T K, Fijneman R J A, Meijer G A, Zhao L, Zhang Y, Largaespada D A, Scott P M, Cormier R T
Abstract excerpt
Kcnq1, which encodes for the pore-forming α-subunit of a voltage-gated potassium channel, was identified as a gastrointestinal (GI) tract cancer susceptibility gene in multiple Sleeping Beauty DNA transposon-based forward genetic screens in mice. To confirm that Kcnq1 has a functional role in GI tract cancer, we created Apc(Min) mice that carried a targeted deletion mutation in Kcnq1. Results demonstrated that...
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