Article

Aberrant TSC-Rheb axis in Oxytocin receptor+ cells mediate stress-induced anxiety

2024-06-25

Abstract excerpt

Stress is a major risk for the onset of several maladaptive processes including pathological anxiety, a diffuse state of heightened apprehension over anticipated threats 1 . Pathological anxiety is prevalent in up to 59% of patients with Tuberous Sclerosis complex (TSC) 2 , a neurodevelopmental disorder (NDD) caused by loss-of-function mutations in genes for Tuberin ( Tsc2 ) and/or Hamartin ( Tsc1 ) that toget...

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Literature Corpus work: 123e3ae9-7383-57dd-b51c-e5dbdfb7c8a4
DOI: 10.1101/2024.06.25.600464

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