Article

No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing

2020-09-05

Abstract excerpt

<h4>Background</h4> The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation of the variance in this heterogeneous condition. Peripheral blood measures of cytokines and chemokines constitute the bulk of evidence with consistent meta-analytic data implicating raised proinflammatory cytokines such as IL6, IL1β and TNF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d161e678-8eed-55fa-b933-2f9874cdab7b
DOI: 10.1101/2020.09.04.20165340

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageingDOI 10.1101/2020.09.04.20165340Read

Immune System Alterations in Depression across Baseline and Flu Vaccine ChallengeSemantic proximity Read

Dissecting depression symptoms: multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulationSemantic proximity Read

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive DisorderSemantic proximity Read

Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.Semantic proximity Read

Dissection of the clinical phenome of major depressive disorder into subdomains and subgroups in relation to activated immune-inflammatory profilesSemantic proximity Read

Peripheral Blood Mononuclear Cell Biomarkers for Major Depressive Disorder: A Transcriptomic ApproachSemantic proximity Read

‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohortsSemantic proximity Read

Anticipated brain molecular aging in major depression.Semantic proximity Read

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP studySemantic proximity Read

Monocyte Dysregulation Defines an MDD-Specific Transcriptional Signature Closely Linked to Clinical MDD TraitsSemantic proximity Read

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?Semantic proximity Read

The immune profile of Major Dysmood Disorder: proof of concept and mechanism using the precision nomothetic psychiatry approachSemantic proximity Read