Article

AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms

2022-07-22

Abstract excerpt

The STING signaling pathway is essential for the innate immune response to DNA viruses and bacteria and is important in tumor immunity. STING binding to cGAMP or to synthetic agonists leads to the activation of the kinase TBK1 which phosphorylates the transcription factor IRF3 which promotes expression of type 1 interferons such as IFNβ to block viral activity. Aberrant type 1 IFN expression is associated with hum...

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Literature Corpus work: d1405d35-1a77-5f13-9932-67934e5884bd
DOI: 10.1101/2022.07.21.500994

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