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Repeated Omicron exposures redirect SARS-CoV-2–specific memory B cell evolution toward the latest variants

21 Aug 2024

Abstract excerpt

Immunological imprinting by ancestral SARS-CoV-2 strains is thought to impede the robust induction of Omicron-specific humoral responses by Omicron-based booster vaccines. Here, we analyzed the specificity and neutralization activity of memory B (B mem ) cells after repeated BA.5 exposure in individuals previously imprinted by ancestral strain–based mRNA vaccines. After a second BA.5 exposure, B mem cells with...

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PMID: 39167666
DOI: 10.1126/scitranslmed.adp9927

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