Article

Tumor immunogenicity regulates host immune responses, and conventional dendritic cell type 2 uptakes the majority of tumor antigens in an orthotopic lung cancer model.

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Human lung cancer carries high genetic alterations, expressing high tumor-specific neoantigens. Although orthotopic murine lung cancer models recapitulate many characteristics of human lung cancers, genetically engineered mouse models have fewer somatic mutations than human lung cancer, resulting in scarce immune cell infiltration and deficient immune responses. The endogenous mouse lun...

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Literature Corpus work: d0fdddef-4228-5aeb-9c50-d2f6ffda7e7f
DOI: 10.21203/rs.3.rs-4438402/v1

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