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Article

RNA populations in immunocompromised patients as reservoirs for novel norovirus variants.

Journal of virology - 1 Dec 2014

Vega Everardo, Donaldson Eric, Huynh Jeremy, Barclay Leslie, Lopman Ben, Baric Ralph, Chen Luke F, Vinjé Jan

Abstract excerpt

UNLABELLED: Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. The majority of norovirus outbreaks are caused by genogroup II.4 (GII.4). Novel GII.4 strains emerge every 2 to 4 years and replace older variants as the dominant norovirus. Novel variants emerge through a combination of recombination, genetic drift, and selection driven by population immunity, but the exact mechanism of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25275120
DOI: 10.1128/JVI.02494-14
PMCID: PMC4249157

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