Article
Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids
2025-05-22
Abstract excerpt
Human noroviruses (HuNoVs), the leading cause of viral gastroenteritis, can now be cultivated in human intestinal enteroids (HIEs). However, indefinite passaging of HuNoVs in HIEs remained a challenge, necessitating the use of patient stool samples as viral inocula. Using RNA-seq, we identified host restriction factors that might limit viral passaging. CXCL10, CXCL11, and CCL5 were among the most upregulated chemo...
Topics
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- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Cancer Cells and Metastasis
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
Identifiers and source
- Literature Corpus work
- 80185f38-13c6-5d4a-a597-e6a72ff26c98
- DOI
- 10.1101/2025.05.22.655571