Article

Replication-deficient Adenovirus 5 Serotypes Induce Type I Interferon and enhance BCG-mediated Immune Response in Co-infected Murine Macrophages

2026-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis (TB) remains a leading global cause of infectious mortality due, in part, to the limited efficacy of the Mycobacterium bovis BCG vaccine against pulmonary TB. Previous studies in mice have shown that stimulating type I interferon (IFN) signaling during BCG vaccination can bolster protection against Mycobacterium tuberculosis , yet clinically feasible delivery strategies for this a...

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Literature Corpus work: d0f979cc-4ce1-5791-b52e-89f58607bdf3
DOI: 10.64898/2026.06.24.734229

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