Article

Increased vaccine efficacy against tuberculosis with a recombinant BCG overexpressing the STING agonist cyclic di-AMP

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis (TB) remains the leading cause of death due to infection globally. Bacillus Calmette Guérin (BCG), a live attenuated bacterial strain, is the only available TB vaccine, but it has poor efficacy in preventing pulmonary TB in adults. There are advantages associated with the BCG platform however, including a remarkable safely profile, billions of administered doses and a public health...

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Literature Corpus work: 393a7a6a-ce2d-58f3-8144-7b135e40fb70
DOI: 10.1101/2025.07.17.665241

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