Article

Uncovering disease-related multicellular pathway modules on large-scale single-cell transcriptomes with scPAFA

2024-03-13

Abstract excerpt

Pathway analysis is a crucial analytical phase in disease research on single-cell RNA sequencing (scRNA-seq) data, offering biological interpretations based on prior knowledge. However, currently available tools for generating cell-level pathway activity scores (PAS) exhibit computational inefficacy in large-scale scRNA-seq datasets. Besides, disease-related pathways are commonly identified by cross-condition comp...

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Literature Corpus work: d0f02508-419c-58ad-b309-fac959496321
DOI: 10.1101/2024.03.11.584023

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