Article

Frequency of mosaicism points towards mutation-prone early cleavage cell divisions in cattle

2016-10-09

Abstract excerpt

It has recently become possible to directly estimate the germ-line de novo mutation ( dnm ) rate by sequencing the whole genome of father-mother-offspring trios, and this has been conducted in human 1–5 , chimpanzee 6 , mice 7 , birds 8 and fish 9 . In these studies dnm ’s are typically defined as variants that are heterozygous in the offspring while being absent in both parents. They are assumed to have oc...

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Literature Corpus work: d0e5c8b1-28dc-5084-a58d-8d47ec1261b8
DOI: 10.1101/079863

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