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Article

The rate of de novo structural variation is increased in in vitro-produced offspring and preferentially affects the paternal genome.

Genome research - 1 Sept 2023

Lee Young-Lim, Bouwman Aniek C, Harland Chad, Bosse Mirte, Costa Monteiro Moreira Gabriel, Veerkamp Roel F, Mullaart Erik, Cambisano Nadine, Groenen Martien A M, Karim Latifa, Coppieters Wouter, Georges Michel, Charlier Carole

Abstract excerpt

Assisted reproductive technologies (ARTs), including in vitro maturation and fertilization (IVF), are increasingly used in human and animal reproduction. Whether these technologies directly affect the rate of de novo mutation (DNM), and to what extent, has been a matter of debate. Here we take advantage of domestic cattle, characterized by complex pedigrees that are ideally suited to detect DNMs and by the...

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Identifiers

PMID: 37793781
DOI: 10.1101/gr.277884.123
PMCID: PMC10620045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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