Article

Gankyrin inhibits ferroptosis through the P53/SLC7A11/GPX4 axis in Triple-negative breast cancer cells

2023-10-05

Abstract excerpt

Gankyrin is found in high levels in triple-negative breast cancer (TNBC) and has been established to form a complex with the E3 ubiquitin ligase MDM2 and p53, resulting in the degradation of p53 in hepatocarcinoma cells. Therefore, this study sought to determine whether gankyrin could inhibit ferroptosis through this mechanism in TNBC cells. The expression of gankyrin was investigated in relation to the prognosis...

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Literature Corpus work: d0e029ac-858a-53cb-84b4-36bb48d45e0a
DOI: 10.21203/rs.3.rs-3379052/v1

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