Article

Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer

2022-04-18

Abstract excerpt

<h4>Background: </h4> Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterized high rates of tumor protein 53 (p53) mutation and limited targeted therapies. Despite being clinically advantageous, direct targeting of mutant p53 has been largely ineffective. Therefore, we hypothesized that there exist pathways upon which p53-mutant TNBC cells rely upon for survival. Methods In v...

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Literature Corpus work: 0fdfadac-9ede-5c0c-97df-c0915c9d58af
DOI: 10.21203/rs.3.rs-1547583/v1

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