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CLDN6 triggers NRF2-mediated ferroptosis through recruiting DLG1/PBK complex in breast cancer

21 Feb 2025

Abstract excerpt

We previously identified CLDN6 as a pivotal tumor suppressor in breast cancer and unexpectedly discovered that overexpression of CLDN6 resulted in characteristic ultrastructural alterations of ferroptosis. However, the exact mechanism by which CLDN6 triggers ferroptosis is still elusive in breast cancer. Our study showed that CLDN6 was associated with ferroptosis in breast cancer patients. The integration of...

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PMID: 39984471
DOI: 10.1038/s41419-025-07448-9

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