Article

Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer Cells

2024-09-02

Abstract excerpt

<title>Abstract</title> <p> Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high rates of tumor protein 53 (TP53) mutation and with limited targeted therapies. Despite being clinically advantageous, direct targeting of mutant TP53 has been challenging. Therefore, we hypothesized that <italic>p53</italic> -mutant TNBC cells rely upon other potentially...

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Literature Corpus work: c06366a8-2e89-5fc2-82e6-faf6b43736ae
DOI: 10.21203/rs.3.rs-4864580/v1

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