Article

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response

2024-09-11

Abstract excerpt

VEGFA administration has been explored as a pro-angiogenic therapy for cardiovascular diseases including heart failure for several years, but with little success. Here we investigate a different approach to augment VEGFA bioavailability: by deleting the VEGFA decoy receptor VEGFR1/FLT1, one can achieve more physiological VEGFA concentrations. We find that following cryoinjury, zebrafish flt1 mutant hearts display...

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Literature Corpus work: f1cc7156-d72c-5d2d-abc3-5960730f902e
DOI: 10.1101/2024.09.11.612516

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