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Article

FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia

18 Sept 2017

Abstract excerpt

Maternal symptoms of preeclampsia (PE) are primarily driven by excess anti-angiogenic factors originating from the placenta. Chief among these are soluble Flt1 proteins (sFlt1s) produced from alternatively polyadenylated mRNA isoforms. Here we used polyadenylation site sequencing (PAS-Seq) of RNA from normal and PE human placentae to interrogate transcriptome-wide gene expression and alternative polyadenylation...

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PMID: 28939845
DOI: 10.1038/s41598-017-11639-6

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