Article

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Approximately 75% of breast cancer cases are estrogen receptor (ER)-positive, with endocrine therapies forming the foundation of treatment. However, therapeutic resistance remains a major clinical challenge, necessitating the identification of new molecular targets. Myosin VI (MVI), a motor protein increasingly linked to cancer, directly interacts with the ER and plays a key role in the spatial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0a40241-fb87-5369-90e9-5f1e5e6eed4e
DOI: 10.1101/2025.11.13.688007

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cellsDOI 10.1101/2025.11.13.688007Read

Identification of a Hormone-regulated Dynamic Nuclear Actin Network Associated with Estrogen Receptor α in Human Breast Cancer Cell NucleiSemantic proximity Read

Hormone signaling and immune programs define differential endocrine responsiveness in high-risk breast tissueSemantic proximity Read

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migrationSemantic proximity Read

Myosins: Tails (and Heads) of Functional DiversitySemantic proximity Read

In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle ResponseSemantic proximity Read

Non-muscle myosin II in disease: mechanisms and therapeutic opportunitiesSemantic proximity Read

Extra-Nuclear Signalling of Estrogen Receptor to Breast Cancer Cytoskeletal Remodelling, Migration and InvasionSemantic proximity Read

Filopodia-mediated basement membrane assembly at pre-invasive tumor boundariesSemantic proximity Read

Gene transcription regulation by ER at the single cell and allele level.Semantic proximity Read

Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancerSemantic proximity Read

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling.Semantic proximity Read

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanismSemantic proximity Read